● Real-World Evidence Platform

A governed, auditable way to turn real-world
oncology data into evidence.

Stemline RWE Intelligence lets analysts ask questions in plain English and get back governed, reproducible answers from Flatiron and Guardant data on Databricks β€” every step recorded, every result traceable, and a human in the loop before anything is trusted.

πŸ”’ Read-only by construction 🧬 Flatiron + Guardant (de-identified RWD) πŸͺͺ Machine-to-machine identity πŸ“‹ Full provenance & review

What it is, in one screen

Six ideas explain the whole platform. The pages above go deeper on each.

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Connected, not copied

We connect to Databricks with a machine identity and read data in place. No bulk data is exported.

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Read-only & least-privilege

The platform can only read the specific data it’s granted, and can only run safe read queries β€” never change anything.

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AI assists, doesn’t decide

Enterprise-licensed AI turns questions into governed queries and formats & explains results. It never owns the data or the verdict.

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Human validation

Every cohort and result starts as a draft. A reviewer validates it before it’s trusted or reused.

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Everything is logged

Every query, cohort, review, and chat is stored with its exact inputs β€” reproducible and inspectable.

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Standard tech, no black box

Built on a mainstream, auditable tech stack. No autonomous-AI framework β€” we control every step.

From one-off scripts to a governed platform

The same real-world data, a fundamentally different way of working with it.

Before Β· one-off scripts
  • Every analysis hand-written β€” definitions drift between analysts
  • Results hard to reproduce; no record of how a number was made
  • No review step β€” trust is assumed, not earned
  • Knowledge tied to one person; little reuse
After Β· governed platform
  • Plain-English questions answered in minutes, via governed tools
  • Reproducible β€” every result pinned to its exact query & data version
  • Human-validated before anything is trusted or reused
  • Consistent, shared definitions β€” institutional memory that compounds

The journey of a question

What happens, end to end, when an analyst asks something β€” every hop is governed and recorded.

Analyst asks in plain English

e.g. β€œHow many ESR1-positive patients had prior CDK4/6i?” β€” typed into the workspace.

AI plans & picks a governed tool

The AI doesn’t touch data directly. It chooses one of our pre-built, validated tools (browse schema, build cohort, run a read-only query, make a chart).

Secure connection to Databricks

The platform authenticates as its service principal, and runs a read-only query on the SQL warehouse β€” compute stays inside Databricks.

Result returns, AI formats it

Aggregated results come back; the AI turns them into a clear table, chart, and plain-language summary with caveats.

Saved as a reusable, versioned artifact

Cohorts and feasibility reports are saved (de-duplicated), starting as Draft.

Reviewed & validated by a human

A reviewer marks it Validated, Needs-changes, or Rejected. Only validated definitions are reused.

Logged to the evidence trail

The exact query, AI model + prompt version, and data version are recorded β€” ready for inspection or a regulator.